Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis. [electronic resource]
- Molecular cancer therapeutics Nov 2009
- 3088-97 p. digital
Publication Type: Journal Article
1538-8514
10.1158/1535-7163.MCT-09-0451 doi
Antineoplastic Combined Chemotherapy Protocols--pharmacology Apoptosis--drug effects Apoptosis Inducing Factor--metabolism Blotting, Western Depsipeptides--administration & dosage Drug Synergism Fas-Associated Death Domain Protein--metabolism Histone Deacetylase Inhibitors--administration & dosage Histone Deacetylases--metabolism Humans Intracellular Signaling Peptides and Proteins--metabolism Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy Phosphorylation--drug effects Protein Kinase C--metabolism Protein Kinase C beta Protein Tyrosine Phosphatase, Non-Receptor Type 6--metabolism Protein-Tyrosine Kinases--metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor--metabolism Signal Transduction--drug effects Syk Kinase TNF-Related Apoptosis-Inducing Ligand--administration & dosage Tetradecanoylphorbol Acetate--pharmacology Tumor Cells, Cultured src-Family Kinases--metabolism