Hong, Eun-Hee <br/><br/>
Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase.  [electronic resource] 

 -  The Journal of biological chemistry  Jan 2010 
 - 1283-95 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M109.058628  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Cartilage--metabolism<br/>Cells, Cultured<br/>Cellular Senescence--genetics<br/>Chondrocytes--metabolism<br/>Cysteine Proteinase Inhibitors--genetics<br/>Enzyme Activation--genetics<br/>Gamma Rays--adverse effects<br/>Humans<br/>Joint Diseases--genetics<br/>Leupeptins--pharmacology<br/>MAP Kinase Kinase 4--genetics<br/>MAP Kinase Signaling System--genetics<br/>Proteasome Endopeptidase Complex--genetics<br/>Proteasome Inhibitors<br/>Rabbits<br/>Reactive Oxygen Species--metabolism<br/>Sirtuin 1--genetics<br/>Up-Regulation--genetics<br/>p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors