Honsho, Shoken <br/><br/>
Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways.  [electronic resource] 

 -  Circulation research  Nov 2009 
 - 1149-58 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1524-4571 
<br/><br/><label>Standard No.: </label>10.1161/CIRCRESAHA.109.208199  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis--physiology<br/>Endomyocardial Fibrosis--metabolism<br/>Extracellular Signal-Regulated MAP Kinases--metabolism<br/>Hypertrophy, Left Ventricular--metabolism<br/>Insulin-Like Growth Factor I--metabolism<br/>Interleukin-1beta--genetics<br/>JNK Mitogen-Activated Protein Kinases--metabolism<br/>Janus Kinase 2--metabolism<br/>Mice<br/>Mice, Mutant Strains<br/>Myocytes, Cardiac--metabolism<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Reactive Oxygen Species--metabolism<br/>Receptors, Interleukin-1--metabolism<br/>STAT5 Transcription Factor--metabolism<br/>Signal Transduction--physiology<br/>Stress, Mechanical<br/>Ventricular Pressure--physiology