TY - GEN AU - Kreeger,Pamela K AU - Mandhana,Roli AU - Alford,Shannon K AU - Haigis,Kevin M AU - Lauffenburger,Douglas A TI - RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects SN - 1538-7445 PY - 2009///1124 KW - Apoptosis KW - drug effects KW - Autocrine Communication KW - Blotting, Western KW - Chemokines KW - Colonic Neoplasms KW - genetics KW - Computational Biology KW - Dual-Specificity Phosphatases KW - Enzyme-Linked Immunosorbent Assay KW - Extracellular Signal-Regulated MAP Kinases KW - metabolism KW - Feedback, Physiological KW - Flow Cytometry KW - Fluorescent Antibody Technique KW - Genes, ras KW - Humans KW - Mutation KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins p21(ras) KW - RNA, Messenger KW - Reverse Transcriptase Polymerase Chain Reaction KW - Transforming Growth Factor beta KW - Tumor Cells, Cultured KW - Tumor Necrosis Factor-alpha KW - pharmacology KW - ras Proteins N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/0008-5472.CAN-09-1921 ER -