Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens. [electronic resource]
- Proteins Feb 2010
- 623-37 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-0134
10.1002/prot.22592 doi
Androgen Antagonists--chemical synthesis Androgen Receptor Antagonists Binding Sites Cluster Analysis Drug Design Flutamide--analogs & derivatives Ligands Molecular Dynamics Simulation Mutation Principal Component Analysis Protein Interaction Domains and Motifs Receptors, Androgen--chemistry