TY  - GEN
AU  - Atack,John R
AU  - Wong,Dean F
AU  - Fryer,Tim D
AU  - Ryan,Christine
AU  - Sanabria,Sandra
AU  - Zhou,Yun
AU  - Dannals,Robert F
AU  - Eng,Wai-si
AU  - Gibson,Raymond E
AU  - Burns,H Donald
AU  - Vega,Jose M
AU  - Vessy,Laura
AU  - Scott-Stevens,Paul
AU  - Beech,John S
AU  - Baron,Jean-Claude
AU  - Sohal,Bindi
AU  - Schrag,Michael L
AU  - Aigbirhio,Franklin I
AU  - McKernan,Ruth M
AU  - Hargreaves,Richard J
TI  - Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans
SN  - 1521-0103
PY  - 2010///0126
KW  - Animals
KW  - Binding Sites
KW  - Brain
KW  - drug effects
KW  - Dose-Response Relationship, Drug
KW  - Flumazenil
KW  - pharmacology
KW  - GABA Agonists
KW  - blood
KW  - GABA-A Receptor Agonists
KW  - GABA-A Receptor Antagonists
KW  - Humans
KW  - Macaca mulatta
KW  - Papio
KW  - Positron-Emission Tomography
KW  - Protein Binding
KW  - Protein Subunits
KW  - Pyridazines
KW  - Radioligand Assay
KW  - Rats
KW  - Species Specificity
KW  - Tissue Distribution
KW  - Triazoles
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/jpet.109.157909
ER  -