Roy Choudhury, Subhasree <br/><br/>
Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification.  [electronic resource] 

 -  Investigational new drugs  Dec 2010 
 - 812-24 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>1573-0646 
<br/><br/><label>Standard No.: </label>10.1007/s10637-009-9324-7  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Angiogenesis Inducing Agents--metabolism<br/>Apoptosis--drug effects<br/>Benzenesulfonates--pharmacology<br/>Caspase 3--metabolism<br/>Cell Cycle--drug effects<br/>Cell Proliferation--drug effects<br/>Cell Shape--drug effects<br/>Cell Survival--drug effects<br/>Cyclin-Dependent Kinase Inhibitor p21--metabolism<br/>Down-Regulation--drug effects<br/>Drug Synergism<br/>Flow Cytometry<br/>Gene Amplification--drug effects<br/>Genistein--pharmacology<br/>Humans<br/>Mitochondria--drug effects<br/>Myeloid Cell Leukemia Sequence 1 Protein<br/>Neuroblastoma--drug therapy<br/>Niacinamide--analogs & derivatives<br/>Phenylurea Compounds<br/>Proto-Oncogene Proteins c-bcl-2--metabolism<br/>Proto-Oncogene Proteins c-myc--genetics<br/>Pyridines--pharmacology<br/>Signal Transduction--drug effects<br/>Sorafenib<br/>Telomerase--metabolism<br/>Treatment Outcome<br/>Tumor Suppressor Protein p53--metabolism<br/>Up-Regulation--drug effects<br/>bcl-2-Associated X Protein--metabolism