TY  - GEN
AU  - Backman,Janne T
AU  - Honkalammi,Johanna
AU  - Neuvonen,Mikko
AU  - Kurkinen,Kaisa J
AU  - Tornio,Aleksi
AU  - Niemi,Mikko
AU  - Neuvonen,Pertti J
TI  - CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe
SN  - 1521-009X
PY  - 2010///0126
KW  - Administration, Oral
KW  - Area Under Curve
KW  - Aryl Hydrocarbon Hydroxylases
KW  - antagonists & inhibitors
KW  - Biotransformation
KW  - Blood Glucose
KW  - drug effects
KW  - Carbamates
KW  - administration & dosage
KW  - Cross-Over Studies
KW  - Cytochrome P-450 CYP2C8
KW  - Drug Interactions
KW  - Enzyme Inhibitors
KW  - Female
KW  - Gemfibrozil
KW  - Genotype
KW  - Glucuronates
KW  - blood
KW  - Half-Life
KW  - Humans
KW  - Hypoglycemic Agents
KW  - Hypolipidemic Agents
KW  - Liver-Specific Organic Anion Transporter 1
KW  - Male
KW  - Models, Biological
KW  - Molecular Probes
KW  - Organic Anion Transporters
KW  - genetics
KW  - Phenotype
KW  - Piperidines
KW  - Young Adult
N1  - Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/dmd.109.029728
ER  -