Backman, Janne T
CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals Dec 2009
- 2359-66 p. digital
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
ISSN: 1521-009X
Standard No.: 10.1124/dmd.109.029728 doi
Subjects--Topical Terms: Administration, Oral Area Under Curve Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors Biotransformation Blood Glucose--drug effects Carbamates--administration & dosage Cross-Over Studies Cytochrome P-450 CYP2C8 Drug Interactions Enzyme Inhibitors--administration & dosage Female Gemfibrozil--administration & dosage Genotype Glucuronates--blood Half-Life Humans Hypoglycemic Agents--administration & dosage Hypolipidemic Agents--administration & dosage Liver-Specific Organic Anion Transporter 1 Male Models, Biological Molecular Probes--administration & dosage Organic Anion Transporters--genetics Phenotype Piperidines--administration & dosage Young Adult