Backman, Janne T

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Dec 2009 - 2359-66 p. digital

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

1521-009X

10.1124/dmd.109.029728 doi


Administration, Oral
Area Under Curve
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Biotransformation
Blood Glucose--drug effects
Carbamates--administration & dosage
Cross-Over Studies
Cytochrome P-450 CYP2C8
Drug Interactions
Enzyme Inhibitors--administration & dosage
Female
Gemfibrozil--administration & dosage
Genotype
Glucuronates--blood
Half-Life
Humans
Hypoglycemic Agents--administration & dosage
Hypolipidemic Agents--administration & dosage
Liver-Specific Organic Anion Transporter 1
Male
Models, Biological
Molecular Probes--administration & dosage
Organic Anion Transporters--genetics
Phenotype
Piperidines--administration & dosage
Young Adult