Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. [electronic resource]
- The Journal of neuroscience : the official journal of the Society for Neuroscience Sep 2009
- 11662-73 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1529-2401
10.1523/JNEUROSCI.1413-09.2009 doi
Animals Area Under Curve Behavior, Animal Brain--metabolism Chromosome Mapping Chromosomes, Human, Pair 1 DNA Mutational Analysis Disease Models, Animal Ethanol--adverse effects G Protein-Coupled Inwardly-Rectifying Potassium Channels--deficiency Gene Expression Regulation--genetics Gene Frequency Genetic Predisposition to Disease Genotype Humans Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Pentobarbital--adverse effects Polymorphism, Single Nucleotide--genetics Pyridines--adverse effects Quantitative Trait Loci Substance Withdrawal Syndrome--genetics Zolpidem