MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. [electronic resource]
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Dec 2009
- 1588-99 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1530-0285
10.1038/modpathol.2009.130 doi
Adult Aged Aged, 80 and over Australia Carcinoma--enzymology Chromosomes, Human, Pair 10 Colorectal Neoplasms--enzymology Cyclin-Dependent Kinase Inhibitor p16--genetics DNA Methylation DNA Modification Methylases--genetics DNA Repair Enzymes--genetics Epigenesis, Genetic Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene Frequency Genetic Predisposition to Disease Germ-Line Mutation Humans Immunohistochemistry Intestinal Mucosa--enzymology Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Odds Ratio Phenotype Polymerase Chain Reaction Polymorphism, Single Nucleotide Prospective Studies Proto-Oncogene Proteins--genetics Proto-Oncogene Proteins p21(ras) Tumor Suppressor Proteins--genetics ras Proteins--genetics