TY  - GEN
AU  - Von Hoff,Daniel D
AU  - LoRusso,Patricia M
AU  - Rudin,Charles M
AU  - Reddy,Josina C
AU  - Yauch,Robert L
AU  - Tibes,Raoul
AU  - Weiss,Glen J
AU  - Borad,Mitesh J
AU  - Hann,Christine L
AU  - Brahmer,Julie R
AU  - Mackey,Howard M
AU  - Lum,Bertram L
AU  - Darbonne,Walter C
AU  - Marsters,James C
AU  - de Sauvage,Frederic J
AU  - Low,Jennifer A
TI  - Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
SN  - 1533-4406
PY  - 2009///0923
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Anilides
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Benzimidazoles
KW  - Carcinoma, Basal Cell
KW  - drug therapy
KW  - Dose-Response Relationship, Drug
KW  - Female
KW  - Gene Expression
KW  - Hedgehog Proteins
KW  - antagonists & inhibitors
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Mutation
KW  - Patched Receptors
KW  - Patched-1 Receptor
KW  - Polymerase Chain Reaction
KW  - Pyridines
KW  - RNA, Messenger
KW  - metabolism
KW  - Receptors, Cell Surface
KW  - genetics
KW  - Sequence Analysis, DNA
KW  - Signal Transduction
KW  - drug effects
KW  - Skin Neoplasms
KW  - Transcription Factors
KW  - Zinc Finger Protein GLI1
N1  - Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1056/NEJMoa0905360
ER  -