Sidique, Shyama <br/><br/>
Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Oct 2009 
 - 5773-7 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2009.07.150  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation<br/>Antiviral Agents--chemical synthesis<br/>Drug Design<br/>Half-Life<br/>Hydrogen-Ion Concentration<br/>Hydrolysis<br/>Pyrazoles--chemical synthesis<br/>RNA Helicases--antagonists & inhibitors<br/>Serine Endopeptidases--metabolism<br/>Serine Proteinase Inhibitors--chemical synthesis<br/>Structure-Activity Relationship<br/>Viral Nonstructural Proteins--antagonists & inhibitors<br/>West Nile Fever--drug therapy<br/>West Nile virus--drug effects