Kumar, Manoj <br/><br/>
In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery.  [electronic resource] 

 -  Molecular diversity  Aug 2010 
 - 595-604 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1573-501X 
<br/><br/><label>Standard No.: </label>10.1007/s11030-009-9172-6  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Antitubercular Agents--chemistry<br/>Binding Sites<br/>Computational Biology--methods<br/>Crystallography, X-Ray<br/>Drug Design<br/>Folic Acid Antagonists--chemistry<br/>Humans<br/>Hydrogen Bonding--drug effects<br/>Ligands<br/>Methotrexate--chemistry<br/>Microbial Sensitivity Tests<br/>Molecular Dynamics Simulation<br/>Molecular Sequence Data<br/>Mycobacterium tuberculosis--drug effects<br/>Ornithine--analogs & derivatives<br/>Peptides--chemistry<br/>Pterins--chemistry<br/>Reproducibility of Results<br/>Substrate Specificity--drug effects<br/>Tetrahydrofolate Dehydrogenase--metabolism<br/>Triazines--chemistry<br/>Tuberculosis--drug therapy