TY  - GEN
AU  - Shio,Marina Tiemi
AU  - Tiemi Shio,Marina
AU  - Eisenbarth,Stephanie C
AU  - Savaria,Myriam
AU  - Vinet,Adrien F
AU  - Bellemare,Marie-Josée
AU  - Harder,Kenneth W
AU  - Sutterwala,Fayyaz S
AU  - Bohle,D Scott
AU  - Descoteaux,Albert
AU  - Flavell,Richard A
AU  - Olivier,Martin
TI  - Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
SN  - 1553-7374
PY  - 2009///1203
KW  - Animals
KW  - Apoptosis Regulatory Proteins
KW  - immunology
KW  - CARD Signaling Adaptor Proteins
KW  - Calcium-Binding Proteins
KW  - Carrier Proteins
KW  - Caspase 1
KW  - Cathepsin B
KW  - metabolism
KW  - Cytoskeletal Proteins
KW  - Disease Models, Animal
KW  - Female
KW  - HSP90 Heat-Shock Proteins
KW  - Hemeproteins
KW  - Humans
KW  - Inflammation
KW  - Interleukin-1beta
KW  - biosynthesis
KW  - Intracellular Signaling Peptides and Proteins
KW  - Malaria
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - NLR Family, Pyrin Domain-Containing 3 Protein
KW  - Neutrophil Infiltration
KW  - Phagocytosis
KW  - Phosphorylation
KW  - Plasmodium chabaudi
KW  - chemistry
KW  - Potassium
KW  - Protein-Tyrosine Kinases
KW  - Proteomics
KW  - Reactive Oxygen Species
KW  - Signal Transduction
KW  - Syk Kinase
KW  - src-Family Kinases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.ppat.1000559
ER  -