Shio, Marina Tiemi <br/><br/>
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.  [electronic resource] 

 -  PLoS pathogens  Aug 2009 
 - e1000559 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1553-7374 
<br/><br/><label>Standard No.: </label>10.1371/journal.ppat.1000559  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis Regulatory Proteins--immunology<br/>CARD Signaling Adaptor Proteins<br/>Calcium-Binding Proteins--immunology<br/>Carrier Proteins--immunology<br/>Caspase 1--immunology<br/>Cathepsin B--metabolism<br/>Cytoskeletal Proteins--immunology<br/>Disease Models, Animal<br/>Female<br/>HSP90 Heat-Shock Proteins--metabolism<br/>Hemeproteins--immunology<br/>Humans<br/>Inflammation--immunology<br/>Interleukin-1beta--biosynthesis<br/>Intracellular Signaling Peptides and Proteins--metabolism<br/>Malaria--immunology<br/>Male<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Knockout<br/>NLR Family, Pyrin Domain-Containing 3 Protein<br/>Neutrophil Infiltration--immunology<br/>Phagocytosis<br/>Phosphorylation--immunology<br/>Plasmodium chabaudi--chemistry<br/>Potassium--metabolism<br/>Protein-Tyrosine Kinases--metabolism<br/>Proteomics<br/>Reactive Oxygen Species--metabolism<br/>Signal Transduction--immunology<br/>Syk Kinase<br/>src-Family Kinases--metabolism