ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. [electronic resource]
- Journal of medicinal chemistry Aug 2009
- 5013-6 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm900851f doi
Adenosine Triphosphate--physiology Animals Antineoplastic Agents--chemical synthesis Binding Sites Carbamates--chemical synthesis Cell Line, Tumor Class Ib Phosphatidylinositol 3-Kinase Crystallography, X-Ray Drug Design Intracellular Signaling Peptides and Proteins--antagonists & inhibitors Isoenzymes--chemistry Mice Mice, Nude Microsomes--metabolism Models, Molecular Phosphatidylinositol 3-Kinases--chemistry Protein Serine-Threonine Kinases--antagonists & inhibitors Pyrazoles--chemical synthesis Pyrimidines--chemical synthesis Structure-Activity Relationship TOR Serine-Threonine Kinases Urea--analogs & derivatives Xenograft Model Antitumor Assays