TY - GEN AU - Lee,Kyu-Won AU - Yook,Jin-Yong AU - Son,Mi-Young AU - Kim,Min-Jeong AU - Koo,Deog-Bon AU - Han,Yong-Mahn AU - Cho,Yee Sook TI - Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway SN - 1557-8534 PY - 2010///0813 KW - Biomarkers KW - Bone Morphogenetic Protein Receptors KW - genetics KW - Cell Differentiation KW - drug effects KW - Cell Line KW - Chromones KW - pharmacology KW - Core Binding Factor Alpha 1 Subunit KW - Embryonic Stem Cells KW - cytology KW - Enzyme Inhibitors KW - Homeodomain Proteins KW - Humans KW - Immunosuppressive Agents KW - Inhibitor of Differentiation Protein 1 KW - Intracellular Signaling Peptides and Proteins KW - antagonists & inhibitors KW - Morpholines KW - Nanog Homeobox Protein KW - Octamer Transcription Factor-3 KW - Osteoblasts KW - Osteogenesis KW - Phosphatidylinositol 3-Kinases KW - metabolism KW - Phosphoinositide-3 Kinase Inhibitors KW - Protein Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - RNA, Messenger KW - Ribosomal Protein S6 Kinases, 70-kDa KW - Signal Transduction KW - Sirolimus KW - Smad Proteins KW - TOR Serine-Threonine Kinases KW - Tacrolimus N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1089/scd.2009.0147 ER -