Lee, Kyu-Won <br/><br/>
Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway.  [electronic resource] 

 -  Stem cells and development  Apr 2010 
 - 557-68 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1557-8534 
<br/><br/><label>Standard No.: </label>10.1089/scd.2009.0147  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Biomarkers<br/>Bone Morphogenetic Protein Receptors--genetics<br/>Cell Differentiation--drug effects<br/>Cell Line<br/>Chromones--pharmacology<br/>Core Binding Factor Alpha 1 Subunit--genetics<br/>Embryonic Stem Cells--cytology<br/>Enzyme Inhibitors--pharmacology<br/>Homeodomain Proteins--genetics<br/>Humans<br/>Immunosuppressive Agents--pharmacology<br/>Inhibitor of Differentiation Protein 1--genetics<br/>Intracellular Signaling Peptides and Proteins--antagonists & inhibitors<br/>Morpholines--pharmacology<br/>Nanog Homeobox Protein<br/>Octamer Transcription Factor-3--genetics<br/>Osteoblasts--cytology<br/>Osteogenesis--drug effects<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Proto-Oncogene Proteins c-akt--antagonists & inhibitors<br/>RNA, Messenger<br/>Ribosomal Protein S6 Kinases, 70-kDa--metabolism<br/>Signal Transduction--drug effects<br/>Sirolimus--pharmacology<br/>Smad Proteins--metabolism<br/>TOR Serine-Threonine Kinases<br/>Tacrolimus--pharmacology