Al Rahim, Md

4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. [electronic resource] - Biochemistry Aug 2009 - 7713-21 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4995

10.1021/bi901088w doi


Animals
Behavior, Animal--drug effects
Cells, Cultured
Conditioning, Classical
Cyclic AMP Response Element-Binding Protein--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
Dizocilpine Maleate--pharmacology
Enzyme Activation
Excitatory Amino Acid Antagonists--pharmacology
Extracellular Signal-Regulated MAP Kinases--metabolism
Fear
Flavones--chemistry
Hippocampus--cytology
Learning--drug effects
MAP Kinase Kinase Kinases--metabolism
MAP Kinase Signaling System--physiology
Male
Memory Disorders--metabolism
Mice
Molecular Structure
Neurons--cytology
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate--antagonists & inhibitors