Short- and long-term cardioprotective effect of darbepoetin-alpha: role of Bcl-2 family proteins. [electronic resource]
- Journal of cardiovascular pharmacology Sep 2009
- 223-31 p. digital
Publication Type: Journal Article
1533-4023
10.1097/FJC.0b013e3181b04d01 doi
Animals Apoptosis--drug effects Cardiotonic Agents--therapeutic use Darbepoetin alfa Dose-Response Relationship, Drug Erythropoietin--analogs & derivatives Glycogen Synthase Kinase 3--metabolism Glycogen Synthase Kinase 3 beta Heart--drug effects Male Myocardial Infarction--pathology Myocardial Reperfusion Injury--drug therapy Myocardium--metabolism Proto-Oncogene Proteins c-akt--metabolism Proto-Oncogene Proteins c-bcl-2--metabolism Random Allocation Rats Rats, Wistar Reactive Oxygen Species--metabolism Severity of Illness Index Signal Transduction--drug effects Stroke Volume--drug effects Time Factors