TY  - GEN
AU  - Lu,Jie
AU  - Kovach,John S
AU  - Johnson,Francis
AU  - Chiang,Jeffrey
AU  - Hodes,Richard
AU  - Lonser,Russell
AU  - Zhuang,Zhengping
TI  - Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms
SN  - 1091-6490
PY  - 2009///0909
KW  - Animals
KW  - Antineoplastic Agents, Alkylating
KW  - therapeutic use
KW  - Blotting, Western
KW  - Cell Cycle Proteins
KW  - metabolism
KW  - DNA Damage
KW  - Dacarbazine
KW  - analogs & derivatives
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Flow Cytometry
KW  - Fluorescent Antibody Technique
KW  - Gene Expression Regulation, Enzymologic
KW  - drug effects
KW  - Glioblastoma
KW  - drug therapy
KW  - Mice
KW  - Mice, SCID
KW  - Neuroblastoma
KW  - Protein Phosphatase 2
KW  - antagonists & inhibitors
KW  - Protein Serine-Threonine Kinases
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins c-akt
KW  - Temozolomide
KW  - Polo-Like Kinase 1
N1  - Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1073/pnas.0905930106
ER  -