Brüning, Ansgar <br/><br/>
Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib.  [electronic resource] 

 -  Investigational new drugs  Oct 2010 
 - 535-42 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1573-0646 
<br/><br/><label>Standard No.: </label>10.1007/s10637-009-9281-1  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Annexin A5--metabolism<br/>Antineoplastic Agents--pharmacology<br/>Benzenesulfonates--pharmacology<br/>Cell Death--drug effects<br/>Cell Line, Tumor<br/>Drug Synergism<br/>Extracellular Signal-Regulated MAP Kinases--metabolism<br/>Female<br/>HIV Protease Inhibitors--pharmacology<br/>Humans<br/>Membrane Potential, Mitochondrial--drug effects<br/>Mitochondria--drug effects<br/>Myeloid Cell Leukemia Sequence 1 Protein<br/>Nelfinavir--pharmacology<br/>Niacinamide--analogs & derivatives<br/>Ovarian Neoplasms--enzymology<br/>Phenylurea Compounds<br/>Phosphorylation--drug effects<br/>Propidium--metabolism<br/>Protein Stability--drug effects<br/>Proto-Oncogene Proteins c-bcl-2--metabolism<br/>Pyridines--pharmacology<br/>Sorafenib