Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. [electronic resource]
- Gastroenterology Oct 2009
- 1358-66.e1-3 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1528-0012
10.1053/j.gastro.2009.06.039 doi
Adenomatous Polyposis Coli--drug therapy Animals Antineoplastic Agents--pharmacology Cell Line, Tumor Cell Survival Colonic Polyps--drug therapy Colorectal Neoplasms--drug therapy Cyclooxygenase 2--metabolism Cyclooxygenase Inhibitors--therapeutic use DNA-Binding Proteins--genetics Down-Regulation Gene Expression Profiling--methods Gene Expression Regulation, Neoplastic Genes, APC Humans Isoxazoles--therapeutic use Lactones--therapeutic use Mice Mice, Mutant Strains Nuclear Receptor Subfamily 4, Group A, Member 2 Oligonucleotide Array Sequence Analysis Osteopontin--genetics Promoter Regions, Genetic RNA Interference Signal Transduction Sulfones--therapeutic use Time Factors Transcription Factors--genetics Transfection Wnt Proteins--metabolism beta Catenin--metabolism