TY  - GEN
AU  - Dahan,Arik
AU  - Amidon,Gordon L
TI  - Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting
SN  - 1522-1547
PY  - 2009///0825
KW  - 2-Pyridinylmethylsulfinylbenzimidazoles
KW  - pharmacology
KW  - ATP Binding Cassette Transporter, Subfamily B, Member 1
KW  - metabolism
KW  - ATP Binding Cassette Transporter, Subfamily G, Member 2
KW  - ATP-Binding Cassette Transporters
KW  - antagonists & inhibitors
KW  - Administration, Oral
KW  - Animals
KW  - Biological Transport
KW  - Caco-2 Cells
KW  - Colon
KW  - drug effects
KW  - Dose-Response Relationship, Drug
KW  - Drug Delivery Systems
KW  - Humans
KW  - Indoles
KW  - Indomethacin
KW  - Intestinal Absorption
KW  - Intestine, Small
KW  - Kinetics
KW  - Male
KW  - Multidrug Resistance-Associated Protein 2
KW  - Multidrug Resistance-Associated Proteins
KW  - Neoplasm Proteins
KW  - Pantoprazole
KW  - Perfusion
KW  - Permeability
KW  - Propionates
KW  - Quinolines
KW  - Rats
KW  - Rats, Wistar
KW  - Sulfasalazine
KW  - administration & dosage
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1152/ajpgi.00102.2009
ER  -