Neumann, Frank

Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor. [electronic resource] - Immunology letters Aug 2009 - 86-92 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0542

10.1016/j.imlet.2009.06.002 doi


Antibodies, Blocking--immunology
Antibody Affinity
Antigens, Neoplasm--immunology
Binding, Competitive
Clone Cells
Epitopes
Graft vs Host Disease--immunology
HLA-A Antigens--genetics
HLA-A2 Antigen
Humans
Immunoglobulin Fab Fragments--immunology
Mutagenesis, Site-Directed
Mutation
Neoplasm Proteins--immunology
Peptide Fragments--immunology
Peptide Library
Protein Binding
Receptors, Antigen, T-Cell--immunology
Repressor Proteins--immunology
T-Cell Antigen Receptor Specificity
T-Lymphocytes, Cytotoxic--immunology