TY  - GEN
AU  - Zhao,Jing Ting
AU  - Hill,Adam P
AU  - Varghese,Anthony
AU  - Cooper,Antony A
AU  - Swan,Heikki
AU  - Laitinen-Forsblom,Päivi J
AU  - Rees,Mark I
AU  - Skinner,Jonathan R
AU  - Campbell,Terence J
AU  - Vandenberg,Jamie I
TI  - Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype
SN  - 1540-8167
PY  - 2010///0426
KW  - Adolescent
KW  - Adult
KW  - Amino Acid Sequence
KW  - Animals
KW  - CHO Cells
KW  - Cell Line
KW  - Child
KW  - Cricetinae
KW  - Cricetulus
KW  - ERG1 Potassium Channel
KW  - Ether-A-Go-Go Potassium Channels
KW  - antagonists & inhibitors
KW  - Female
KW  - Gene Silencing
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Molecular Sequence Data
KW  - Mutation
KW  - genetics
KW  - Pedigree
KW  - Phenotype
KW  - Protein Structure, Tertiary
KW  - Protein Transport
KW  - Severity of Illness Index
KW  - Young Adult
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1111/j.1540-8167.2009.01468.x
ER  -