Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. [electronic resource]
- The Biochemical journal Jul 2009
- 171-80 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1470-8728
10.1042/BJ20090471 doi
Amino Acid Sequence Amino Acid Substitution Antioxidants--metabolism Biocatalysis Cell Line, Tumor Conserved Sequence Cullin Proteins--metabolism Cysteine--genetics Humans Intracellular Signaling Peptides and Proteins--chemistry Kelch-Like ECH-Associated Protein 1 Models, Molecular Molecular Sequence Data Mutant Proteins--chemistry NF-E2-Related Factor 2--metabolism Protein Binding Protein Stability Response Elements--genetics Structure-Activity Relationship Tryptophan--genetics Ubiquitination