TY  - GEN
AU  - Wen,Bo
AU  - Zhou,Mingyan
TI  - Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s
SN  - 1872-7786
PY  - 2009///0903
KW  - Antipsychotic Agents
KW  - pharmacokinetics
KW  - Biotransformation
KW  - Chlorpromazine
KW  - Chromatography, High Pressure Liquid
KW  - Cytochrome P-450 CYP2D6
KW  - metabolism
KW  - Cytochrome P-450 CYP2D6 Inhibitors
KW  - Dose-Response Relationship, Drug
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Glutathione
KW  - Humans
KW  - In Vitro Techniques
KW  - Microsomes, Liver
KW  - enzymology
KW  - Quinidine
KW  - Quinones
KW  - Tandem Mass Spectrometry
KW  - Thioridazine
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.cbi.2009.05.014
ER  -