Wen, Bo <br/><br/>
Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.  [electronic resource] 

 -  Chemico-biological interactions  Oct 2009 
 - 220-6 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1872-7786 
<br/><br/><label>Standard No.: </label>10.1016/j.cbi.2009.05.014  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antipsychotic Agents--pharmacokinetics<br/>Biotransformation<br/>Chlorpromazine--pharmacokinetics<br/>Chromatography, High Pressure Liquid<br/>Cytochrome P-450 CYP2D6--metabolism<br/>Cytochrome P-450 CYP2D6 Inhibitors<br/>Dose-Response Relationship, Drug<br/>Enzyme Inhibitors--pharmacology<br/>Glutathione--metabolism<br/>Humans<br/>In Vitro Techniques<br/>Microsomes, Liver--enzymology<br/>Quinidine--pharmacology<br/>Quinones--pharmacokinetics<br/>Tandem Mass Spectrometry<br/>Thioridazine--pharmacokinetics