TY  - GEN
AU  - Ménard,Delphine
AU  - Niculescu-Duvaz,Ion
AU  - Dijkstra,Harmen P
AU  - Niculescu-Duvaz,Dan
AU  - Suijkerbuijk,Bart M J M
AU  - Zambon,Alfonso
AU  - Nourry,Arnaud
AU  - Roman,Esteban
AU  - Davies,Lawrence
AU  - Manne,Helen A
AU  - Friedlos,Frank
AU  - Kirk,Ruth
AU  - Whittaker,Steven
AU  - Gill,Adrian
AU  - Taylor,Richard D
AU  - Marais,Richard
AU  - Springer,Caroline J
TI  - Novel potent BRAF inhibitors: toward 1 nM compounds through optimization of the central phenyl ring
SN  - 1520-4804
PY  - 2009///0812
KW  - Allosteric Site
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Inhibitory Concentration 50
KW  - Melanoma
KW  - drug therapy
KW  - Mutation, Missense
KW  - Phenols
KW  - Proto-Oncogene Proteins B-raf
KW  - antagonists & inhibitors
KW  - Pyridines
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm900242c
ER  -