Shor, Boris <br/><br/>
A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.  [electronic resource] 

 -  BMC immunology  May 2009 
 - 28 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1471-2172 
<br/><br/><label>Standard No.: </label>10.1186/1471-2172-10-28  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>B-Lymphocytes--drug effects<br/>Carrier Proteins--genetics<br/>Catalytic Domain--genetics<br/>Cell Proliferation--drug effects<br/>Cells, Cultured<br/>Embryonic Development--genetics<br/>Gene Knock-In Techniques<br/>Heterozygote<br/>Immune System--embryology<br/>Lymphocyte Activation--drug effects<br/>Mice<br/>Mutation<br/>Phosphatidylinositol 3-Kinases--immunology<br/>Phosphotransferases (Alcohol Group Acceptor)--genetics<br/>Signal Transduction--drug effects<br/>Sirolimus--pharmacology<br/>T-Lymphocytes--drug effects<br/>TOR Serine-Threonine Kinases<br/>Tacrolimus Binding Protein 1A--antagonists & inhibitors