Braeuning, Albert <br/><br/>
The glycogen synthase kinase inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) is a partial agonist of the aryl hydrocarbon receptor.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Aug 2009 
 - 1576-80 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.109.027821  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Aryl Hydrocarbon Receptor Nuclear Translocator--metabolism<br/>Basic Helix-Loop-Helix Transcription Factors<br/>Cell Line, Tumor<br/>Cytochrome P-450 CYP1A1--biosynthesis<br/>Dose-Response Relationship, Drug<br/>Drug Partial Agonism<br/>Enzyme Induction<br/>Glycogen Synthase Kinase 3--antagonists & inhibitors<br/>Glycogen Synthase Kinase 3 beta<br/>Hepatocytes--drug effects<br/>Indoles--pharmacology<br/>Male<br/>Maleimides--pharmacology<br/>Mice<br/>Mice, Inbred C3H<br/>Mice, Knockout<br/>Polychlorinated Dibenzodioxins--pharmacology<br/>Promoter Regions, Genetic--drug effects<br/>Protein Kinase Inhibitors--pharmacology<br/>RNA, Messenger--biosynthesis<br/>Receptors, Aryl Hydrocarbon--agonists<br/>Signal Transduction--drug effects<br/>Transcriptional Activation--drug effects<br/>Wnt Proteins--metabolism<br/>Wnt3 Protein<br/>beta Catenin--genetics