Remke, Marc <br/><br/>
High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response.  [electronic resource] 

 -  Blood  Jul 2009 
 - 1053-62 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1528-0020 
<br/><br/><label>Standard No.: </label>10.1182/blood-2008-10-186536  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adolescent<br/>Antineoplastic Combined Chemotherapy Protocols--therapeutic use<br/>Child<br/>Child, Preschool<br/>Chromosome Deletion<br/>Chromosomes, Human, Pair 6--genetics<br/>Comparative Genomic Hybridization<br/>Cyclin-Dependent Kinase Inhibitor p27<br/>Female<br/>Gene Dosage<br/>Humans<br/>Intracellular Signaling Peptides and Proteins--genetics<br/>Male<br/>Multicenter Studies as Topic--statistics & numerical data<br/>Neoplasm Proteins--genetics<br/>Phosphatidylinositol 3-Kinases--genetics<br/>Precursor T-Cell Lymphoblastic Leukemia-Lymphoma--drug therapy<br/>Prognosis<br/>Proto-Oncogene Proteins c-akt--genetics<br/>Receptor, Notch1--genetics<br/>Signal Transduction--genetics<br/>Transforming Growth Factor beta--genetics<br/>Treatment Outcome