Zhou, Jinming <br/><br/>
Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants.  [electronic resource] 

 -  Investigational new drugs  Jun 2010 
 - 291-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1573-0646 
<br/><br/><label>Standard No.: </label>10.1007/s10637-009-9251-7  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Androgen Antagonists--chemical synthesis<br/>Androgen Receptor Antagonists<br/>Antineoplastic Agents, Hormonal--chemical synthesis<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Chalcones--chemical synthesis<br/>Drug Design<br/>Drug Resistance, Neoplasm--genetics<br/>Drug Screening Assays, Antitumor<br/>Humans<br/>Male<br/>Molecular Structure<br/>Mutation--drug effects<br/>Norisoprenoids--chemical synthesis<br/>Receptors, Androgen--genetics<br/>Structure-Activity Relationship