TY  - GEN
AU  - Bonnefous,Céline
AU  - Payne,Joseph E
AU  - Roppe,Jeffrey
AU  - Zhuang,Hui
AU  - Chen,Xiaohong
AU  - Symons,Kent T
AU  - Nguyen,Phan M
AU  - Sablad,Marciano
AU  - Rozenkrants,Natasha
AU  - Zhang,Yan
AU  - Wang,Li
AU  - Severance,Daniel
AU  - Walsh,John P
AU  - Yazdani,Nahid
AU  - Shiau,Andrew K
AU  - Noble,Stewart A
AU  - Rix,Peter
AU  - Rao,Tadimeti S
AU  - Hassig,Christian A
AU  - Smith,Nicholas D
TI  - Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models
SN  - 1520-4804
PY  - 2009///0602
KW  - Administration, Oral
KW  - Animals
KW  - Cell Line
KW  - Constriction, Pathologic
KW  - chemically induced
KW  - Disease Models, Animal
KW  - Drug Discovery
KW  - Enzyme Inhibitors
KW  - administration & dosage
KW  - Fluoroquinolones
KW  - Formaldehyde
KW  - toxicity
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Lipopolysaccharides
KW  - Mice
KW  - Nitric Oxide Synthase Type II
KW  - antagonists & inhibitors
KW  - Pain
KW  - drug therapy
KW  - Protein Multimerization
KW  - drug effects
KW  - Protein Structure, Quaternary
KW  - Pyrazines
KW  - Quinolones
KW  - Structure-Activity Relationship
KW  - Substrate Specificity
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm900173b
ER  -