Bonnefous, Céline <br/><br/>
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.  [electronic resource] 

 -  Journal of medicinal chemistry  May 2009 
 - 3047-62 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm900173b  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Cell Line<br/>Constriction, Pathologic--chemically induced<br/>Disease Models, Animal<br/>Drug Discovery<br/>Enzyme Inhibitors--administration & dosage<br/>Fluoroquinolones--administration & dosage<br/>Formaldehyde--toxicity<br/>Humans<br/>Inhibitory Concentration 50<br/>Lipopolysaccharides--toxicity<br/>Mice<br/>Nitric Oxide Synthase Type II--antagonists & inhibitors<br/>Pain--drug therapy<br/>Protein Multimerization--drug effects<br/>Protein Structure, Quaternary<br/>Pyrazines--administration & dosage<br/>Quinolones--administration & dosage<br/>Structure-Activity Relationship<br/>Substrate Specificity