Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. [electronic resource]
- Molecular cancer therapeutics Apr 2009
- 959-70 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1535-7163
10.1158/1535-7163.MCT-08-0905 doi
Animals Antineoplastic Combined Chemotherapy Protocols--therapeutic use Apoptosis--drug effects Blotting, Western Boronic Acids--administration & dosage Bortezomib Cell Proliferation--drug effects Curcumin--administration & dosage Disease Models, Animal Drug Resistance, Neoplasm--drug effects Drug Synergism Humans Immunoenzyme Techniques Male Mice Mice, Nude Multiple Myeloma--drug therapy NF-kappa B--metabolism Proto-Oncogene Proteins c-akt--metabolism Pyrazines--administration & dosage Signal Transduction Thalidomide--administration & dosage Vascular Endothelial Growth Factor A--metabolism Xenograft Model Antitumor Assays