A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Apr 2009
- 6939-44 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.0900833106 doi
Amino Acid Sequence Amino Acids--genetics Aurora Kinase A Aurora Kinase B Aurora Kinases Chromosomal Proteins, Non-Histone--metabolism Chromosome Structures--metabolism Conserved Sequence Enzyme Activation Glycine--genetics HeLa Cells Humans Microtubule-Associated Proteins--metabolism Mitosis Models, Molecular Phosphorylation Protein Binding Protein Serine-Threonine Kinases--chemistry Protein Structure, Quaternary Protein Structure, Tertiary Sequence Alignment Substrate Specificity