Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. [electronic resource]
- American journal of physiology. Cell physiology Jun 2009
- C1258-70 p. digital
Publication Type: Journal Article
0363-6143
10.1152/ajpcell.00105.2009 doi
Activin Receptors, Type I--antagonists & inhibitors Adaptor Proteins, Signal Transducing Animals Benzamides--pharmacology Carrier Proteins--metabolism Cell Differentiation--drug effects Cell Size--drug effects Cells, Cultured Creatine Kinase--metabolism Dioxoles--pharmacology Follistatin--pharmacology Humans Insulin-Like Growth Factor I--metabolism Mice Mice, SCID Muscle Fibers, Skeletal--drug effects Muscle Proteins--metabolism Myoblasts, Skeletal--drug effects Myostatin--antagonists & inhibitors Organ Size Phosphorylation Protein Kinase Inhibitors--pharmacology Protein Kinases--genetics Proteins--metabolism Proto-Oncogene Proteins c-akt--metabolism RNA Interference RNA, Small Interfering--metabolism Rapamycin-Insensitive Companion of mTOR Protein Regulatory-Associated Protein of mTOR Ribosomal Protein S6 Kinases, 70-kDa--metabolism SKP Cullin F-Box Protein Ligases--metabolism Signal Transduction Smad2 Protein--genetics Smad3 Protein--genetics TOR Serine-Threonine Kinases Transfection Tripartite Motif Proteins Ubiquitin-Protein Ligases--metabolism