TY - GEN AU - O'Keefe,Barry R AU - Vojdani,Fakhrieh AU - Buffa,Viviana AU - Shattock,Robin J AU - Montefiori,David C AU - Bakke,James AU - Mirsalis,Jon AU - d'Andrea,Anna-Lisa AU - Hume,Steven D AU - Bratcher,Barry AU - Saucedo,Carrie J AU - McMahon,James B AU - Pogue,Gregory P AU - Palmer,Kenneth E TI - Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component SN - 1091-6490 PY - 2009///0512 KW - Algal Proteins KW - genetics KW - Animals KW - Cell Proliferation KW - drug effects KW - Cells, Cultured KW - Cervix Uteri KW - surgery KW - Cytokines KW - biosynthesis KW - Drug Evaluation, Preclinical KW - Female KW - HIV Envelope Protein gp120 KW - metabolism KW - HIV Fusion Inhibitors KW - adverse effects KW - HIV Infections KW - prevention & control KW - HIV-1 KW - Humans KW - Lectins KW - Plant Lectins KW - Protein Binding KW - Rabbits KW - Tissue Culture Techniques KW - Tissue Transplantation KW - Nicotiana N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural UR - https://doi.org/10.1073/pnas.0901506106 ER -