TY - GEN AU - Debenham,John S AU - Madsen-Duggan,Christina B AU - Wang,Junying AU - Tong,Xinchun AU - Lao,Julie AU - Fong,Tung M AU - Schaeffer,Marie-Therese AU - Xiao,Jing Chen AU - Huang,Cathy C R-R AU - Shen,Chun-Pyn AU - Sloan Stribling,D AU - Shearman,Lauren P AU - Strack,Alison M AU - Euan Macintyre,D AU - Hale,Jeffrey J AU - Walsh,Thomas F TI - Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation SN - 1464-3405 PY - 2009///0821 KW - Administration, Oral KW - Animals KW - Cannabinoid Receptor Agonists KW - Cannabinoids KW - chemistry KW - Chemistry, Pharmaceutical KW - methods KW - Drug Design KW - Humans KW - Inhibitory Concentration 50 KW - Obesity KW - drug therapy KW - Protein Structure, Tertiary KW - Pyrimidines KW - Rats KW - Receptor, Cannabinoid, CB1 KW - agonists KW - Receptor, Cannabinoid, CB2 KW - Structure-Activity Relationship N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.bmcl.2009.03.005 ER -