TY  - GEN
AU  - Vachal,Petr
AU  - Fletcher,Joan M
AU  - Fong,Tung M
AU  - Huang,Cathy C R-R
AU  - Lao,Julie
AU  - Xiao,Jing C
AU  - Shen,Chun-Pyn
AU  - Strack,Alison M
AU  - Shearman,Lauren
AU  - Stribling,Sloan
AU  - Chen,Richard Z
AU  - Frassetto,Andrea
AU  - Tong,Xinchun
AU  - Wang,Junying
AU  - Ball,Richard G
AU  - Tsou,Nancy N
AU  - Hickey,Gerard J
AU  - Thompson,Donald F
AU  - Faidley,Terry D
AU  - Nicolich,Susan
AU  - Achanfuo-Yeboah,Joana
AU  - Hora,Donald F
AU  - Hale,Jeffrey J
AU  - Hagmann,William K
TI  - 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity
SN  - 1520-4804
PY  - 2009///0506
KW  - Animals
KW  - Anti-Obesity Agents
KW  - chemical synthesis
KW  - Biological Availability
KW  - Body Weight
KW  - drug effects
KW  - Dogs
KW  - Drug Inverse Agonism
KW  - Eating
KW  - Hepatocytes
KW  - metabolism
KW  - Humans
KW  - In Vitro Techniques
KW  - Macaca mulatta
KW  - Microsomes, Liver
KW  - Models, Molecular
KW  - Piperazines
KW  - Rats
KW  - Receptor, Cannabinoid, CB1
KW  - antagonists & inhibitors
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Sulfonamides
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm900063x
ER  -