Montini, Eugenio

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. [electronic resource] - The Journal of clinical investigation Apr 2009 - 964-75 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1558-8238

10.1172/JCI37630 doi


Animals
Base Sequence
Cyclin-Dependent Kinase Inhibitor p16--deficiency
DNA Primers--genetics
Gammaretrovirus--genetics
Genes, p16
Genetic Therapy--adverse effects
Genetic Vectors--adverse effects
Hematopoietic Stem Cell Transplantation--adverse effects
Lentivirus--genetics
Mice
Mice, Knockout
Mice, Transgenic
Mutation
Neoplasms, Experimental--etiology
Terminal Repeat Sequences