Cell-type specific activation of p38 and ERK mediates calcitonin gene-related peptide involvement in tolerance to morphine-induced analgesia. [electronic resource]
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug 2009
- 2576-86 p. digital
Publication Type: Journal Article
1530-6860
10.1096/fj.08-128348 doi
Analgesia Analgesics, Opioid--administration & dosage Animals Astrocytes--drug effects Calcitonin Gene-Related Peptide--physiology Drug Tolerance--physiology Inflammation Mediators--metabolism Interleukin-1beta--metabolism MAP Kinase Signaling System Male Microglia--drug effects Mitogen-Activated Protein Kinases--metabolism Models, Neurological Morphine--administration & dosage Prostaglandin-E Synthases Prostaglandin-Endoperoxide Synthases--metabolism Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha--metabolism Up-Regulation--drug effects p38 Mitogen-Activated Protein Kinases--metabolism