Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest. [electronic resource]
- Cancer research Apr 2009
- 2748-56 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-08-2690 doi
Cell Growth Processes--physiology Cellular Senescence--physiology Chemotaxis Cyclin-Dependent Kinase Inhibitor p21--biosynthesis DNA Methylation Humans Intracellular Signaling Peptides and Proteins--genetics Melanoma--enzymology Neoplastic Stem Cells--pathology Promoter Regions, Genetic Protein-Tyrosine Kinases--biosynthesis RNA, Small Interfering--genetics Signal Transduction Spheroids, Cellular Syk Kinase Transfection Tumor Suppressor Protein p53--metabolism Up-Regulation src Homology Domains