ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. [electronic resource]
- American journal of physiology. Heart and circulatory physiology May 2009
- H1236-43 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0363-6135
10.1152/ajpheart.00100.2009 doi
Animals Cardiovascular Agents--pharmacology Cyclic GMP-Dependent Protein Kinases--metabolism Cyclic Nucleotide Phosphodiesterases, Type 5--metabolism Disease Models, Animal Enzyme Activation Flavonoids--pharmacology Glycogen Synthase Kinase 3--metabolism Glycogen Synthase Kinase 3 beta Hemodynamics--drug effects Male Mice Mice, Inbred ICR Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3--antagonists & inhibitors Myocardial Contraction--drug effects Myocardial Infarction--enzymology Myocardial Reperfusion Injury--enzymology Myocardium--enzymology Nitric Oxide Synthase Type II--metabolism Nitric Oxide Synthase Type III--metabolism Phosphodiesterase 5 Inhibitors Phosphodiesterase Inhibitors--pharmacology Phosphorylation Piperazines--pharmacology Protein Kinase Inhibitors--pharmacology Proto-Oncogene Proteins c-bcl-2--metabolism Purines--pharmacology Signal Transduction--drug effects Sildenafil Citrate Sulfones--pharmacology Time Factors bcl-2-Associated X Protein--metabolism