The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo. [electronic resource]
- Clinical cancer research : an official journal of the American Association for Cancer Research Mar 2009
- 2022-30 p. digital
Publication Type: Journal Article
1078-0432
10.1158/1078-0432.CCR-08-1826 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Aurora Kinase B Aurora Kinases Camptothecin--analogs & derivatives Cell Line, Tumor Cell Proliferation--drug effects Drug Synergism Enzyme Inhibitors--pharmacology Humans Irinotecan Mice Organophosphates--pharmacology Polyploidy Protein Serine-Threonine Kinases--antagonists & inhibitors Quinazolines--pharmacology Topoisomerase I Inhibitors Xenograft Model Antitumor Assays