Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. [electronic resource]
- The Biochemical journal May 2009
- 305-15 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1470-8728
10.1042/BJ20081909 doi
Animals Blotting, Western Cell Line Cell Proliferation--drug effects Cholesterol--metabolism Chromatography, High Pressure Liquid DNA-Binding Proteins--metabolism Desmosterol--metabolism HeLa Cells Humans Hydroxycholesterols--pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology Liver X Receptors Lovastatin--pharmacology Macrophages--cytology Mice Nerve Tissue Proteins--deficiency Orphan Nuclear Receptors Oxidoreductases Acting on CH-CH Group Donors--deficiency RNA, Messenger--genetics Receptors, Cytoplasmic and Nuclear--metabolism Reverse Transcriptase Polymerase Chain Reaction Sterol Regulatory Element Binding Protein 1--metabolism Sterol Regulatory Element Binding Protein 2--metabolism Sterols--biosynthesis