TY  - GEN
AU  - Chen,Chi
AU  - Krausz,Kristopher W
AU  - Shah,Yatrik M
AU  - Idle,Jeffrey R
AU  - Gonzalez,Frank J
TI  - Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity
SN  - 1520-5010
PY  - 2009///0707
KW  - Acetaminophen
KW  - toxicity
KW  - Animals
KW  - Carnitine
KW  - analogs & derivatives
KW  - Chemical and Drug Induced Liver Injury
KW  - Chromatography, Liquid
KW  - Cytochrome P-450 CYP2E1
KW  - deficiency
KW  - Fatty Acids
KW  - metabolism
KW  - Glutathione
KW  - Liver Diseases
KW  - Mass Spectrometry
KW  - Metabolomics
KW  - Mice
KW  - Mice, Knockout
KW  - PPAR alpha
KW  - antagonists & inhibitors
KW  - Time Factors
N1  - Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/tx800464q
ER  -